Main Street Elementary is in the South Park area, between the 110 Harbor freeway to the west and Avalon to the east. It is south of Vernon and north of Slauson. The Main Street #48, Avalon Blvd. #51/52, Broadway #45/46/745, Slauson #108, Vernon #105/705 and Harbor Transitway buses provide transit access to the school.

     The main entrance to the school is on 53rd Street, just east of Main Street. Street parking should be available near the school on weekends.